Nature Communications (Feb 2021)

Innate immune evasion revealed in a colorectal zebrafish xenograft model

  • Vanda Póvoa,
  • Cátia Rebelo de Almeida,
  • Mariana Maia-Gil,
  • Daniel Sobral,
  • Micaela Domingues,
  • Mayra Martinez-Lopez,
  • Miguel de Almeida Fuzeta,
  • Carlos Silva,
  • Ana Rita Grosso,
  • Rita Fior

DOI
https://doi.org/10.1038/s41467-021-21421-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Zebrafish has emerged as an important vertebrate model to study tumor biology and immune response. Here, using a zebrafish xenograft model, the authors show that the engraftment capacity of human colorectal cancer cell lines is influenced by innate immune response and immunoediting.