Pathogenic basis and modern prospects in early diagnostics of nephrosclerosis in children with vesicoureteral reflux

Abstract

The present article summarizes modern conceptions of tubulointerstitial fibrosis development mechanisms in children with vesicoureteral reflux. The review deals with the questions of extracellular matrix components accumulation and disintegration, tissue hypoxia, remodeling of blood flow, concentration changes in inflammation, sclerosis and angiogenesis biomarkers in the progress of nephrosclerosis

Keywords

• children
• cytokines
• nephrosclerosis
• renal parenchymal damage markers
• vesicoureteral reflux