Avaliação da biodegradação de matrizes porosas à base de hidroxiapatita para aplicação como fontes radioativas em braquiterapia Evaluation of the biodegradation of porous hydroxyapatite matrices for application as radioactive sources in brachytherapy

Abstract

Porous ceramic materials based on calcium phosphate compounds (CPC) have been studied aiming at different biomedical applications such as implants, drug delivery systems and radioactive sources for brachytherapy. Two kinds of hydroxyapatite (HAp) powders and their ceramic bodies were characterized by a combination of different techniques (XRF, BET method, SEM, ICP/AES and neutron activation analysis - NAA) to evaluate their physico-chemical and microstructural characteristics in terms of chemical composition, segregated phases, microstructure, porosity, chemical and thermal stability, biodegradation and incorporation of substances in their structures. The results revealed that these systems presented potential for use as porous biodegradable radioactive sources able to be loaded with a wide range of radionuclides for cancer treatment by the brachytherapy technique.

Keywords

• hydroxyapatite
• biodegradation
• brachytherapy