Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses

Qian Chen; Mairene Coto-Llerena; Aleksei Suslov; Raphael Dias Teixeira; Isabel Fofana; Sandro Nuciforo; Maike Hofmann; Robert Thimme; Nina Hensel; Volker Lohmann; Charlotte K. Y. Ng; George Rosenberger; Stefan Wieland; Markus H. Heim

doi:10.1038/s41467-021-25218-x

Nature Communications (Aug 2021)

Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses

Qian Chen,
Mairene Coto-Llerena,
Aleksei Suslov,
Raphael Dias Teixeira,
Isabel Fofana,
Sandro Nuciforo,
Maike Hofmann,
Robert Thimme,
Nina Hensel,
Volker Lohmann,
Charlotte K. Y. Ng,
George Rosenberger,
Stefan Wieland,
Markus H. Heim

Affiliations

Qian Chen: Department of Biomedicine, University of Basel
Mairene Coto-Llerena: Department of Biomedicine, University of Basel
Aleksei Suslov: Department of Biomedicine, University of Basel
Raphael Dias Teixeira: Biozentrum, University of Basel
Isabel Fofana: Department of Biomedicine, University of Basel
Sandro Nuciforo: Department of Biomedicine, University of Basel
Maike Hofmann: Department of Medicine II, University Hospital Freiburg
Robert Thimme: Department of Medicine II, University Hospital Freiburg
Nina Hensel: Department of Medicine II, University Hospital Freiburg
Volker Lohmann: Department of Infectious Diseases, Molecular Virology, Centre for Integrative Infectious Disease Research (CIID), University of Heidelberg
Charlotte K. Y. Ng: Department for BioMedical Research (DBMR), Oncogenomics Lab, University of Bern
George Rosenberger: Department of Biomedicine, University of Basel
Stefan Wieland: Department of Biomedicine, University of Basel
Markus H. Heim: Department of Biomedicine, University of Basel

DOI: https://doi.org/10.1038/s41467-021-25218-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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A genetic variant in the IFN-lambda 4 gene has been associated with poor hepatitis C virus prognosis but it is not clear how this functions. Here the authors show that IFN-lambda 4 promotes ER stress and inhibits presentation of HCV epitopes to CD8+ T cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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