BIO Web of Conferences (Jan 2024)
Modeling the properties of new potential modifiers of the medium for cryopreservation of fish sperm
Abstract
To model the antioxidant activity (antiradical activity against the hydroxyl radical and superoxide anion radical) of a number of new heteroatomic organic compounds containing OH and NH groups, calculations were performed within the framework of density functional theory using the B3LYP functional. The energy effects of reactions of the studied compounds with hydroxyl radical and superoxide anion radical were calculated. Based on the calculations performed for a series of 12 compounds, leading compounds were identified for which high antiradical activity with respect to both radicals is predicted. These leading compounds can be considered as promising for use as an exogenous antioxidant additive to the basic cryoprotective medium to increase the cryoresistance of fish sperm.