Communications Biology (Jul 2021)
Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations
- Chaojie Yang,
- Brian Hallmark,
- Jin Choul Chai,
- Timothy D. O’Connor,
- Lindsay M. Reynolds,
- Alexis C. Wood,
- Michael Seeds,
- Yii-Der Ida Chen,
- Lyn M. Steffen,
- Michael Y. Tsai,
- Robert C. Kaplan,
- Martha L. Daviglus,
- Lawrence J. Mandarino,
- Amanda M. Fretts,
- Rozenn N. Lemaitre,
- Dawn K. Coletta,
- Sarah A. Blomquist,
- Laurel M. Johnstone,
- Chandra Tontsch,
- Qibin Qi,
- Ingo Ruczinski,
- Stephen S. Rich,
- Rasika A. Mathias,
- Floyd H. Chilton,
- Ani Manichaikul
Affiliations
- Chaojie Yang
- Center for Public Health Genomics, University of Virginia
- Brian Hallmark
- Center for Biomedical Informatics and Biostatistics, University of Arizona
- Jin Choul Chai
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Timothy D. O’Connor
- Institute for Genome Sciences; Program in Personalized and Genomic Medicine; Department of Medicine, University of Maryland School of Medicine
- Lindsay M. Reynolds
- Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake School of Medicine
- Alexis C. Wood
- USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine
- Michael Seeds
- Molecular Medicine, Wake Forest University
- Yii-Der Ida Chen
- Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Lyn M. Steffen
- Division of Epidemiology and Community Health, University of Minnesota School of Public Health
- Michael Y. Tsai
- Department of Laboratory Medicine and Pathology, University of Minnesota
- Robert C. Kaplan
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Martha L. Daviglus
- Institute for Minority Health Research, University of Illinois at Chicago
- Lawrence J. Mandarino
- Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine
- Amanda M. Fretts
- Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington
- Rozenn N. Lemaitre
- Department of Medicine, Cardiovascular Health Research Unit, University of Washington
- Dawn K. Coletta
- Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine
- Sarah A. Blomquist
- Department of Nutritional Sciences, University of Arizona College of Agriculture and Life Sciences
- Laurel M. Johnstone
- University of Arizona Genetics Core, University of Arizona
- Chandra Tontsch
- Department of Nutritional Sciences, University of Arizona College of Agriculture and Life Sciences
- Qibin Qi
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Ingo Ruczinski
- Department of Biostatistics, Johns Hopkins University
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia
- Rasika A. Mathias
- Department of Medicine, Johns Hopkins University
- Floyd H. Chilton
- Department of Nutritional Sciences, University of Arizona College of Agriculture and Life Sciences
- Ani Manichaikul
- Center for Public Health Genomics, University of Virginia
- DOI
- https://doi.org/10.1038/s42003-021-02431-4
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 12
Abstract
Yang et al. examine whether genetic ancestry is associated with genetic variation in fatty acid desaturases and plasma phospholipid levels of long chain polyunsaturated fatty acids (LC-PUFAs) in Hispanic Americans. They find strong associations between Amerind genetic ancestry and LC-PUFA levels; and report that the well-known FADS rs174537 variant was associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides.
