Nature Communications (Jul 2021)

Coordination of endothelial cell positioning and fate specification by the epicardium

  • Pearl Quijada,
  • Michael A. Trembley,
  • Adwiteeya Misra,
  • Jacquelyn A. Myers,
  • Cameron D. Baker,
  • Marta Pérez-Hernández,
  • Jason R. Myers,
  • Ronald A. Dirkx,
  • Ethan David Cohen,
  • Mario Delmar,
  • John M. Ashton,
  • Eric M. Small

DOI
https://doi.org/10.1038/s41467-021-24414-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

Read online

It remains unclear how spatial information controls endothelial cell identity and behavior in the developing heart. Here the authors perform single cell RNA sequencing at key developmental timepoints in mice to interrogate cellular contributions to coronary vessel patterning and maturation in the epicardium.