Circular RNAs Regulate Glucose Metabolism in Cancer Cells

Abstract

Xiaoyu Ji, Wei Sun, Chengzhou Lv, Jiapeng Huang, Hao Zhang Department of Thyroid Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of ChinaCorrespondence: Hao Zhang Email [email protected]: Circular RNAs (circRNAs) were originally thought to result from RNA splicing errors. However, it has been shown that circRNAs can regulate cancer onset and progression in various ways. They can regulate cancer cell proliferation, differentiation, invasion, and metastasis. Moreover, they modulate glucose metabolism in cancer cells through different mechanisms such as directly regulating glycolytic enzymes and glucose transporter (GLUT) or indirectly regulating signal transduction pathways. In this review, we elucidate on the role of circRNAs in regulating glucose metabolism in cancer cells, which partly explains the pathogenesis of malignant tumors, and provides new therapeutic targets or new diagnostic and prognostic markers for human cancers.Keywords: circRNAs, glucose metabolism, Warburg effect, signaling pathway, targeted therapy

Keywords

• circrnas
• glucose metabolism
• warburg effect
• signaling pathway
• targeted therapy