Nature Communications (Jun 2020)
The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
- S. Di Blasio,
- G. F. van Wigcheren,
- A. Becker,
- A. van Duffelen,
- M. Gorris,
- K. Verrijp,
- I. Stefanini,
- G. J. Bakker,
- M. Bloemendal,
- A. Halilovic,
- A. Vasaturo,
- G. Bakdash,
- S. V. Hato,
- J. H. W. de Wilt,
- J. Schalkwijk,
- I. J. M. de Vries,
- J. C. Textor,
- E. H. van den Bogaard,
- M. Tazzari,
- C. G. Figdor
Affiliations
- S. Di Blasio
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- G. F. van Wigcheren
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- A. Becker
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- A. van Duffelen
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- M. Gorris
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- K. Verrijp
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- I. Stefanini
- Division of Biomedical Sciences, The University of Warwick
- G. J. Bakker
- Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- M. Bloemendal
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- A. Halilovic
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- A. Vasaturo
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- G. Bakdash
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- S. V. Hato
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- J. H. W. de Wilt
- Department of Surgery, Radboud University Medical Center
- J. Schalkwijk
- Department of Dermatology, Radboud University Medical Center
- I. J. M. de Vries
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- J. C. Textor
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- E. H. van den Bogaard
- Department of Dermatology, Radboud University Medical Center
- M. Tazzari
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- C. G. Figdor
- Department of Tumour Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- DOI
- https://doi.org/10.1038/s41467-020-16583-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Conventional co-culture systems often lack physiological complexity of the tumor microenvironment. Here, the authors report an organotypic skin melanoma culture and use this model to investigate the tumor induced suppression on dendritic cells.
