Effects of using soluble Beta-glucan on immune responses against infectious bronchitis disease in broiler chicks

Abstract

The study was conducted to investigate the effects of soluble β-glucan derived from yeast cell wall isolated from Saccharomyces cerevisiae in drinking water on immune response post routine vaccination and challenge with local isolates of infectious bronchitis virus. Four hundred Ross 308 broiler chicks (from 1 to 40 days old) were divided randomly into four equal groups (diet and drinking water offered ad libitum). G1 was given 225μg/ml of soluble β-glucan in drinking water from day 1 to the end of the experiment and vaccinated with H120 vaccine at one day old by intranasal and ocular drop methods, and Ma5 strain vaccine at 14 days old by spray method. G2 was received 225μg/ml of soluble β-glucan in drinking water from one day to the end of the experiment and considered as control positive. G3 was vaccinated as G1 but without given soluble β-glucan, and G4 considered as control negative (not vaccinated not treated). Results showed that G1 was given significant (P<0.05) increase of antibody titer and gave high production against challenge and increased in IL2 level compared to other groups. In conclusion, we found that the soluble β-glucan enhanced the cellular and humoral immunity against IBV.