Nature Communications (Jul 2016)
Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
Abstract
A common susceptibility haplotype for renal cell carcinoma is located on chromosome 12p12.1. Here, the authors show that the variant rs7132434 alters binding of the AP-1 transcription factor, which increases the expression of BHLHE41in renal cells.