Heliyon (Jan 2021)
The broadband power shifts in entorhinal EEG are related to the firing of grid cells
Abstract
The relationship between the firing of the grid cell and mesoscopic neural oscillations is one of the key issues to understand the neural mechanism of grid cells. Previous studies have focused more on the correspondence between neuronal firing and phases of oscillations, such as phase precession. There are also some conclusions about the relationship between the activity of grid cells and the intensity of neural oscillations, such as the disappearance of grid pattern caused by the blocking of theta rhythm, but the correlation between the firing rates of grid cells and the narrowband power of neural oscillations or the broadband LFP power is still scarce. Through analyzing the records of spike times of grid cells and local entorhinal EEG obtained by Hafting et al., in the spatial navigation experiment, we find that grid cells are, to a large proportion, a kind of broadband-shift neurons, and the positive correlation between grid cell activity and power of low theta and gamma bands was observed. These results have well verified, promoted, and connected many scattered research conclusions, such as the broadband shift phenomenon of hippocampal neurons, the influence of low theta activity on the firing pattern of grid cells, and the positive correlation between single-cell activity and gamma-band activity. This work is of great significance for the study of the neural mechanism of grid cells at the micro and mesoscopic levels, and may also inspire the use of indicators such as broadband power as markers for grid cell activity.
