Store-independent modulation of Ca2+ entry through Orai by Septin 7

Bipan Kumar Deb; Trayambak Pathak; Gaiti Hasan

doi:10.1038/ncomms11751

Nature Communications (May 2016)

Store-independent modulation of Ca2+ entry through Orai by Septin 7

Bipan Kumar Deb,
Trayambak Pathak,
Gaiti Hasan

Affiliations

Bipan Kumar Deb: National Centre for Biological Sciences, Tata Institute of Fundamental Research
Trayambak Pathak: National Centre for Biological Sciences, Tata Institute of Fundamental Research
Gaiti Hasan: National Centre for Biological Sciences, Tata Institute of Fundamental Research

DOI: https://doi.org/10.1038/ncomms11751
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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Orai channels are well known to mediate store-operated calcium entry. Here authors show that in neurons of the Drosophilaflight circuit, Septin 7 acts as a negative regulator of Orai channels, surprisingly, by modulating store-independent calcium entry through Orai.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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