Journal of Pain Research (Oct 2022)

Effect of AMPK Subunit Alpha 2 Polymorphisms on Postherpetic Pain Susceptibility in Southwestern Han Chinese

  • Mei Y,
  • Mu Y,
  • Wang W,
  • Tan BT,
  • Chen YH,
  • Li YP,
  • Zhu D,
  • Li W,
  • Cui J,
  • Yu LH

Journal volume & issue
Vol. Volume 15
pp. 3319 – 3326


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Yang Mei,1,2 Yang Mu,3 Win Wang,2 Bo-Tao Tan,1 Yao-Hua Chen,4 Yu-Ping Li,4 Dan Zhu,4 Wei Li,2 Jian Cui,4 Le-Hua Yu1 1Department of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Pain Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, People’s Republic of China; 3Department of Rehabilitation Medicine, Chongqing University Fuling Hospital, Chongqing, People’s Republic of China; 4Department of Pain Medicine, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Jian Cui; Le-Hua Yu, Email [email protected]; [email protected]: Adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) can influence energy metabolism. Energy metabolism imbalance is closely associated with the occurrence of neuropathic pain (NeP). Rs10789038 and rs2796498 are genetic polymorphisms of PRKAA2, the gene encoding AMPK, which is closely related to energy metabolism imbalance. This study aimed to explore the relationship between PRKAA2 and postherpetic neuralgia (PHN) in the southwestern Chinese Han population.Methods: This study enrolled 132 PHN patients and 118 healthy subjects. The rs10789038 and rs2796498 PRKAA2 genotypes were identified in all participants. The association between these single nucleotide polymorphisms and PHN susceptibility was evaluated in the dominant and recessive models. Haplotype analysis of patients with PHN and healthy controls was performed.Results: The PHN patients were older than the healthy subjects (P 0.05). Genotypes and allele frequencies differed significantly between PHN patients and healthy subjects in the rs10789038 polymorphism (P 0.05). In addition, the GG haplotype of rs10789038-rs2796498 correlated negatively with PHN occurrence in haplotype analysis (P G genetic polymorphism in the southwestern Chinese Han population.Keywords: AMPK, PRKAA2, polymorphism, postherpetic neuralgia