Nature Communications (Nov 2022)

CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever

  • Bo Shu,
  • Justin S. G. Ooi,
  • Aaron W. K. Tan,
  • Thiam-Seng Ng,
  • Wanwisa Dejnirattisai,
  • Juthathip Mongkolsapaya,
  • Guntur Fibriansah,
  • Jian Shi,
  • Victor A. Kostyuchenko,
  • Gavin R. Screaton,
  • Shee-Mei Lok

DOI
https://doi.org/10.1038/s41467-022-34415-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 10

Abstract

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The extracellular secreted NS1 (sNS1) is a major factor contributing to dengue hemorrhagic fever. Here, Shu et al. report sNS1 exists in multiple oligomeric states and presents a tetrameric structure.