SIMULTANEOUS DETERMINATION OF AMINOTRIAZOLE AND TRIAZOLOPYRIMIDINONE - SUBSTRATE AND INTERMEDIATE IN THE SYNTHESIS OF «TRIAZIDE» BY HPLC

A. V. Baklykov; A. A. Tumashov; S. K. Kotovskaya; E. N. Ulomskiy; G. L. Rusinov; V. L. Rusinov; O. N. Chupahin; V. N. Charushin

Разработка и регистрация лекарственных средств (Jan 2019)

SIMULTANEOUS DETERMINATION OF AMINOTRIAZOLE AND TRIAZOLOPYRIMIDINONE - SUBSTRATE AND INTERMEDIATE IN THE SYNTHESIS OF «TRIAZIDE» BY HPLC

A. V. Baklykov,
A. A. Tumashov,
S. K. Kotovskaya,
E. N. Ulomskiy,
G. L. Rusinov,
V. L. Rusinov,
O. N. Chupahin,
V. N. Charushin

Affiliations

A. V. Baklykov: I.Ya. Postovsky Institute of Organic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
A. A. Tumashov: I.Ya. Postovsky Institute of Organic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
S. K. Kotovskaya: I.Ya. Postovsky Institute of Organic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
E. N. Ulomskiy: I.Ya. Postovsky Institute of Organic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
G. L. Rusinov: I.Ya. Postovsky Institute of Organic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
V. L. Rusinov: I.Ya. Postovsky Institute of Organic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
O. N. Chupahin: I.Ya. Postovsky Institute of Organic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
V. N. Charushin: I.Ya. Postovsky Institute of Organic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin

Journal volume & issue: Vol. 0, no. 2
pp. 146 – 150

Abstract

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Method of simultaneous determination of aminotriazole and triazolopyrimidinone using HPLC with UV-detection was developed. For best chromatographic performance Zorbax NH2 amino phase column (Agilent Technologies, USA) was selected. The applicability of the developed method for providing technological control of the 1st stage of «Triazide» production was approved according to the results of validation procedure.

Published in Разработка и регистрация лекарственных средств

ISSN: 2305-2066 (Print); 2658-5049 (Online)
Publisher: LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
Country of publisher: Russian Federation
LCC subjects: Social Sciences: Industries. Land use. Labor: Special industries and trades: Pharmaceutical industry
Website: https://www.pharmjournal.ru/

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