Risk factors analysis of clinical features with surgical resection rate and prognosis of petroclival meningioma with main body in posterior fossa

Abstract

Objective: Our retrospective study aimed to investigate the relation of clinical features with surgical resection degree and prognosis of petroclival meningioma (PCM) whose main body in the posterior fossa and summarized the experience of surgery. We worked on improving the cure rate of PCM patients from both clinical data analysis and surgical experience. Methods: We retrospectively analyzed 62 patients of the main body of PCM locating in the posterior fossa. Clinical data included basic information of patients, video of surgery, and post-operation follow-up. Clinical results were evaluated by Karnofsky Performance Score (KPS). The degree of surgical resection was evaluated by Simpson grade. Tumor resection degree and postoperative complications were performed by univariate and multivariate analyses. Results: The analyses showed gross total resection achieved in 50 cases (81.97%), and subtotal resection in 11 cases (18.03%). There were 38 cases (62%) without complications after operation. The preoperative KPS score of 19 cases were ≥ 80, and the postoperative KPS score of 51 cases were ≥80. The results showed that resection degree and quality of life were connected to Edema and adhesion of the brainstem, and postoperative complications were associated with age, tumor size and wrap of vessel. Conclusions: Edema and adhesion of the brainstem caused by tumor compression is an independent risk factor of surgical resection degree and quality of life in patients with PCM; Age, tumor size and wrap of vessel are independent risk factors of postoperative complications in patients with PCM.

Keywords

• Risk factors analysis
• Petroclival meningioma
• Posterior fossa