TDG is a novel tumor suppressor of liver malignancies

Abstract

In a recent publication, we demonstrated that conditional deletion of the gene encoding thymine DNA glycosylase (TDG) leads to a late onset of hepatocellular carcinoma (HCC). TDG loss causes disruption in active DNA demethylation in the liver and dysregulation of the farnesoid X receptor and small heterodimer partner (FXR-SHP) regulatory cascade. This leads to a loss of bile acid and glucose homeostasis, which predisposes mice to HCC.

Keywords

• thymine dna glycosylase
• ten eleven translocation
• fxr
• bile acid
• glucose intolerance
• liver cancer
• hepatocellular carcinoma
• active dna demethylation
• shp