AIDS complicated with <i>Salmonella Typhi</i> subdural abscess: a case report

Abstract

Subdural abscesses are located between the dura mater and the subarachnoid space， which are primarily caused by Staphylococci and Streptococci， etc. Subdural abscesses caused by Salmonella Typhi are extremely rare. In this article， a patient with acquired immunodeficiency syndrome （AIDS） presented with a subdural abscess with fever and headache. Blood culture and next-generation sequencing （NGS） of cerebrospinal fluid were indicative of Salmonella Typhi infection. He was treated with sensitive antibiotics based on drug sensitivity testing combined with surgical drainage， and Salmonella Typhi was cultured in the drainage sample. During 4-month postoperative follow-up， relevant symptoms were mitigated and imaging examination results were normal. This case prompts that intracranial infection caused by Salmonella Typhi is extremely rare， which can occur in immunocompromised population. Blood culture， pus culture and NGS are of significant value in differential diagnosis of Salmonella Typhi infection. After the diagnosis is confirmed， sensitive antibiotics combined with surgical treatment can achieve high efficacy.

Keywords

• acquired immunodeficiency syndrome|<i>salmonella typhi</i>|subdural abscess|diagnostic imaging