Pleural nodular mesothelial/histiocytic hyperplasia associated with syphilis

Kyra B. Berg, MD; Peter D. Liebling, MD; Melanie J. Kubik, MD; Richard Attanoos, MD; Francoise Galateau-Salle, MD; Victor Roggli, MD; Mark Wick, MD; Andrew M. Churg, MD

Human Pathology: Case Reports (Sep 2018)

Pleural nodular mesothelial/histiocytic hyperplasia associated with syphilis

Kyra B. Berg, MD,
Peter D. Liebling, MD,
Melanie J. Kubik, MD,
Richard Attanoos, MD,
Francoise Galateau-Salle, MD,
Victor Roggli, MD,
Mark Wick, MD,
Andrew M. Churg, MD

Affiliations

Kyra B. Berg, MD: Department of Pathology, University of British Columbia, Vancouver, Canada
Peter D. Liebling, MD: Department of Pulmonary and Critical Care Medicine, Kaiser Permanente San Diego, San Diego, CA, United States
Melanie J. Kubik, MD: Department of Pathology and Laboratory Medicine, Kaiser Permanente San Diego Medical Center, San Diego, CA, United States
Richard Attanoos, MD: Department of Pathology, University of Wales and Cardiff University, Cardiff, UK
Francoise Galateau-Salle, MD: MESOPATH-MESOBANK, Centre Leon Berard, Lyon, France
Victor Roggli, MD: Department of Pathology, Duke University Medical Center, Durham, NC, United States
Mark Wick, MD: Department of Pathology, University of Virginia Medical Center, Charlottesville,VA, United States
Andrew M. Churg, MD: Department of Pathology, University of British Columbia, Vancouver, Canada; Department of Pathology, Vancouver General Hospital, Vancouver, Canada; Corresponding author: Department of Pathology, Vancouver General Hospital, JPPN 1401, 910 West 10th Ave., Vancouver, BC, Canada.

Journal volume & issue: Vol. 13
pp. 18 – 20

Abstract

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Nodular mesothelial/histiocytic hyperplasia (NMHH) is a benign reactive phenomenon that can occur at any mesothelial site. We report the case of a 33 year old male who presented with chest pain and a pleural effusion, and after several months of investigation was found to have positive syphilis serology and NMHH of the pleura that was positive for spirochetes on immunohistochemical stain. NHMM has been previously reported to be caused by physical, inflammatory/infectious, or neoplastic irritation of mesothelium at various sites. This is the first reported case of NMHH associated with syphilis. Keywords: Nodular mesothelial/histiocytic hyperplasia, Syphilis, Spirochete

Published in Human Pathology: Case Reports

ISSN: 2214-3300 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Pathology
Website: http://www.journals.elsevier.com/human-pathology-case-reports/

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