Nature Communications (Aug 2020)
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate
- Akhilesh Pandey,
- Eric W. Stawiski,
- Steffen Durinck,
- Harsha Gowda,
- Leonard D. Goldstein,
- Mustafa A. Barbhuiya,
- Markus S. Schröder,
- Sreelakshmi K. Sreenivasamurthy,
- Sun-Whe Kim,
- Sameer Phalke,
- Kushal Suryamohan,
- Kayla Lee,
- Papia Chakraborty,
- Vasumathi Kode,
- Xiaoshan Shi,
- Aditi Chatterjee,
- Keshava Datta,
- Aafaque A. Khan,
- Tejaswini Subbannayya,
- Jing Wang,
- Subhra Chaudhuri,
- Sanjiv Gupta,
- Braj Raj Shrivastav,
- Bijay S. Jaiswal,
- Satish S. Poojary,
- Shushruta Bhunia,
- Patricia Garcia,
- Carolina Bizama,
- Lorena Rosa,
- Wooil Kwon,
- Hongbeom Kim,
- Youngmin Han,
- Thakur Deen Yadav,
- Vedam L. Ramprasad,
- Amitabha Chaudhuri,
- Zora Modrusan,
- Juan Carlos Roa,
- Pramod Kumar Tiwari,
- Jin-Young Jang,
- Somasekar Seshagiri
Affiliations
- Akhilesh Pandey
- Institute of Bioinformatics
- Eric W. Stawiski
- Bioinformatics and Computational Biology Department, Genentech Inc
- Steffen Durinck
- Bioinformatics and Computational Biology Department, Genentech Inc
- Harsha Gowda
- Institute of Bioinformatics
- Leonard D. Goldstein
- Bioinformatics and Computational Biology Department, Genentech Inc
- Mustafa A. Barbhuiya
- Institute of Bioinformatics
- Markus S. Schröder
- Molecular Biology Department, Genentech Inc.
- Sreelakshmi K. Sreenivasamurthy
- Institute of Bioinformatics
- Sun-Whe Kim
- Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Seoul National University Hospital, Seoul National University College of Medicine
- Sameer Phalke
- Research and Development Department, MedGenome Labs Pvt. Ltd.
- Kushal Suryamohan
- Research and Development Department, MedGenome Inc
- Kayla Lee
- Research and Development Department, MedGenome Inc
- Papia Chakraborty
- Research and Development Department, MedGenome Inc
- Vasumathi Kode
- Research and Development Department, MedGenome Inc
- Xiaoshan Shi
- Research and Development Department, MedGenome Inc
- Aditi Chatterjee
- Institute of Bioinformatics
- Keshava Datta
- Institute of Bioinformatics
- Aafaque A. Khan
- Institute of Bioinformatics
- Tejaswini Subbannayya
- Institute of Bioinformatics
- Jing Wang
- Research and Development Department, MedGenome Inc
- Subhra Chaudhuri
- Molecular Biology Department, Genentech Inc.
- Sanjiv Gupta
- Department of Pathology, Cancer Hospital and Research Institute
- Braj Raj Shrivastav
- Department of Surgical Oncology, Cancer Hospital and Research Institute
- Bijay S. Jaiswal
- Molecular Biology Department, Genentech Inc.
- Satish S. Poojary
- Jiwaji University
- Shushruta Bhunia
- Jiwaji University
- Patricia Garcia
- Department of Pathology, Millennium Institute on Immunology and Immunotherapy, School of Medicine, Pontificia Universidad Católica de Chile
- Carolina Bizama
- Department of Pathology, Millennium Institute on Immunology and Immunotherapy, School of Medicine, Pontificia Universidad Católica de Chile
- Lorena Rosa
- Applied Molecular and Cellular Biology PhD Program Universidad De la Frontera
- Wooil Kwon
- Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Seoul National University Hospital, Seoul National University College of Medicine
- Hongbeom Kim
- Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Seoul National University Hospital, Seoul National University College of Medicine
- Youngmin Han
- Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Seoul National University Hospital, Seoul National University College of Medicine
- Thakur Deen Yadav
- Department of Surgery, Postgraduate Institute of Medical Education and Research
- Vedam L. Ramprasad
- Research and Development Department, MedGenome Labs Pvt. Ltd.
- Amitabha Chaudhuri
- Research and Development Department, MedGenome Inc
- Zora Modrusan
- Molecular Biology Department, Genentech Inc.
- Juan Carlos Roa
- Department of Pathology, Millennium Institute on Immunology and Immunotherapy, School of Medicine, Pontificia Universidad Católica de Chile
- Pramod Kumar Tiwari
- Jiwaji University
- Jin-Young Jang
- Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Seoul National University Hospital, Seoul National University College of Medicine
- Somasekar Seshagiri
- Molecular Biology Department, Genentech Inc.
- DOI
- https://doi.org/10.1038/s41467-020-17880-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Gallbladder cancer incidence shows characteristic geographic patterns. Here the authors perform a genomic analysis of gallbladder cancers in patients from countries with high incidence (South Korea, India and Chile) and identify ELF3 and other significantly mutated genes not previously associated with gallbladder cancer.
