Ferroptosis in the treatment of colorectal cancer

Abstract

Ferroptosis is a form of programmed cell death caused by accumulation of iron-dependent lipophilic reactive oxygen species. Its occurrence depends on the comprehensive changes of intracellular iron homeostasis, lipid metabolism and antioxidant system. Colorectal cancer is one of the common malignant tumors of the digestive tract. It can effectively inhibit the proliferation of colorectal cancer cells, reverse drug resistance and improve the radio sensitivity of colorectal cancer cells by inducing ferroptosis pathway.

Keywords

• colorectal cancer|ferroptosis|cancer treatment|radiation therapy|chemotherapy