Communications Biology (Sep 2021)

HA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants

  • Sebastian Fritzwanker,
  • Lionel Moulédous,
  • Catherine Mollereau,
  • Carine Froment,
  • Odile Burlet-Schiltz,
  • Felix Effah,
  • Alexis Bailey,
  • Mariana Spetea,
  • Rainer K. Reinscheid,
  • Stefan Schulz,
  • Andrea Kliewer

DOI
https://doi.org/10.1038/s42003-021-02580-6
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 10

Abstract

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Fritzwanker et al. develop a knock-in transgenic mouse line in which the hemagglutinin epitope tag sequence is fused with the amino-terminus of the µ-opioid receptor. Their model enables more efficient immunodetection of G protein-coupled receptors.