Experimental and Molecular Medicine (Apr 2024)

Entosis: the core mechanism and crosstalk with other cell death programs

  • Sunghoon Kim,
  • Donghyuk Lee,
  • Sung Eun Kim,
  • Michael Overholtzer

DOI
https://doi.org/10.1038/s12276-024-01227-w
Journal volume & issue
Vol. 56, no. 4
pp. 870 – 876

Abstract

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Abstract Cell death pathways play critical roles in organism development and homeostasis as well as in the pathogenesis of various diseases. While studies over the last decade have elucidated numerous different forms of cell death that can eliminate cells in various contexts, how certain mechanisms impact physiology is still not well understood. Moreover, recent studies have shown that multiple forms cell death can occur in a cell population, with different forms of death eliminating individual cells. Here, we aim to describe the known molecular mechanisms of entosis, a non-apoptotic cell engulfment process, and discuss signaling mechanisms that control its induction as well as its possible crosstalk with other cell death mechanisms.