A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif

Johana C. Misas Villamil; André N. Mueller; Fatih Demir; Ute Meyer; Bilal Ökmen; Jan Schulze Hüynck; Marlen Breuer; Helen Dauben; Joe Win; Pitter F. Huesgen; Gunther Doehlemann

doi:10.1038/s41467-019-09472-8

Nature Communications (Apr 2019)

A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif

Johana C. Misas Villamil,
André N. Mueller,
Fatih Demir,
Ute Meyer,
Bilal Ökmen,
Jan Schulze Hüynck,
Marlen Breuer,
Helen Dauben,
Joe Win,
Pitter F. Huesgen,
Gunther Doehlemann

Affiliations

Johana C. Misas Villamil: Botanical Institute and Cluster of Excellence on Plant Sciences, University of Cologne
André N. Mueller: Max Planck Institute for Terrestrial Microbiology
Fatih Demir: Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich
Ute Meyer: Botanical Institute and Cluster of Excellence on Plant Sciences, University of Cologne
Bilal Ökmen: Botanical Institute and Cluster of Excellence on Plant Sciences, University of Cologne
Jan Schulze Hüynck: Botanical Institute and Cluster of Excellence on Plant Sciences, University of Cologne
Marlen Breuer: Max Planck Institute for Terrestrial Microbiology
Helen Dauben: Botanical Institute and Cluster of Excellence on Plant Sciences, University of Cologne
Joe Win: The Sainsbury Laboratory, Norwich Research Park
Pitter F. Huesgen: Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich
Gunther Doehlemann: Botanical Institute and Cluster of Excellence on Plant Sciences, University of Cologne

DOI: https://doi.org/10.1038/s41467-019-09472-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Pit2 is a secreted Ustilago maydis effector that contributes to corn smut disease by inhibiting papain-like cysteine proteases (PLCPs) in maize. Here Misas Villamil et al. show that Pit2 mimics PLCP substrates, and is cleaved to release a peptide that blocks PLCP activity and represses host immunity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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