Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

• Jie Yang,
• Vladimir O. Talibov,
• Stefan Peintner,
• Claire Rhee,
• Vasanthanathan Poongavanam,
• Matthis Geitmann,
• Matteo Rossi Sebastiano,
• Bernd Simon,
• Janosch Hennig,
• Doreen Dobritzsch,
• U. Helena Danielson,
• Jan Kihlberg

Affiliations

Jie Yang

Department of ChemistryBMC, Uppsala University, Uppsala, Sweden

Vladimir O. Talibov

Department of ChemistryBMC, Uppsala University, Uppsala, Sweden

Stefan Peintner

Department of ChemistryBMC, Uppsala University, Uppsala, Sweden

Claire Rhee

Department of ChemistryBMC, Uppsala University, Uppsala, Sweden

Vasanthanathan Poongavanam

Department of ChemistryBMC, Uppsala University, Uppsala, Sweden

Matthis Geitmann

Beactica AB, Uppsala, Sweden

Matteo Rossi Sebastiano

Department of ChemistryBMC, Uppsala University, Uppsala, Sweden

Bernd Simon

Structural and Computational Biology Unit, EMBL Heidelberg, Heidelberg, Germany

Janosch Hennig

Structural and Computational Biology Unit, EMBL Heidelberg, Heidelberg, Germany

Doreen Dobritzsch

Department of ChemistryBMC, Uppsala University, Uppsala, Sweden

U. Helena Danielson

Department of ChemistryBMC, Uppsala University, Uppsala, Sweden

Jan Kihlberg

Department of ChemistryBMC, Uppsala University, Uppsala, Sweden