INFLUENCE OF ARTIFICIAL HUMAN ADAPTATION TO INTERMITTENT NORMOBARIC ANOXIA ON THE OPTIONS OF ERYTHROCYTES OF CIRCULATING BLOOD

Abstract

Purpose: to estimate changes and dynamics of the options of circulating blood erythrocytes in artificial human adaptation to intermittent normobaric hypoxia.Materials and methods: Sixteen healthy male volunteers aged 20-24 years were underwent to course of artificial adaptation to intermittent normobaric hypoxia (AAINH): 1,5 h daily for 30 days in the gas atmosphere with an oxygen content of 13.5%. Venous blood samples were collected before exposure (day 0), day after exposure, then after 3 and 6 months.Results: adaptive changes of red blood cells after the course of AAINH were registered in all cases. Moderate reduction of the number of circulating erythrocytes, hematocrit and average erythrocyte volume were noticed. At the same time such parameter as hemoglobin concentration and it’s content in red blood cell was significantly higher than an average one. The long-term follow up demonstrated that the registered trends were continued.Summary: use of AAINH accompanied with increasing oxygen capacity of circulating blood (due to the synthesis of improved oxygen capasity of red cells), while «determination» to prevent the deterioration of its rheological properties.

Keywords

• artificial adaptation
• intermittent normobaric hypoxia
• circulating erythrocytes
• erythropoiesis