Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein

Abstract

Henipaviruses such as Nipah virus (NiV) cause severe encephalitis with high fatality rates in humans. NiV fusion (F) glycoprotein is a key target of the host immune response. Here, Byrne et al. isolate ten neutralizing antibodies against NiV prefusion F and provide a structural analysis of the antibodies and defined eight neutralization-sensitive epitopes on NiV F.