Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm

Mohammed Ferdous-Ur Rahman; Yue Yang; Bao T. Le; Avik Dutta; Julia Posyniak; Patrick Faughnan; Mohammad A. Sayem; Nadine S. Aguilera; Golam Mohi

doi:10.1038/s41467-022-32928-3

Nature Communications (Sep 2022)

Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm

Mohammed Ferdous-Ur Rahman,
Yue Yang,
Bao T. Le,
Avik Dutta,
Julia Posyniak,
Patrick Faughnan,
Mohammad A. Sayem,
Nadine S. Aguilera,
Golam Mohi

Affiliations

Mohammed Ferdous-Ur Rahman: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine
Yue Yang: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine
Bao T. Le: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine
Avik Dutta: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine
Julia Posyniak: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine
Patrick Faughnan: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine
Mohammad A. Sayem: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine
Nadine S. Aguilera: Department of Pathology, University of Virginia School of Medicine
Golam Mohi: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine

DOI: https://doi.org/10.1038/s41467-022-32928-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Chronic inflammation is frequently observed in patients with myeloproliferative neoplasms (MPN). Here the authors observe elevated levels of IL-1α and IL-1β in MPN patients and show that IL-1 contributes to clonal expansion and bone marrow fibrosis in a mouse model of MPN, proposing targeting of IL1R1 as therapeutic intervention.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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