Phosphor-IWS1-dependent U2AF2 splicing regulates trafficking of CAR-E-positive intronless gene mRNAs and sensitivity to viral infection

Abstract

Laliotis et al. examine the role of the AKT3-phoshorylated RNA processing factor IWS1 and the IWS1 phosphorylation-dependent alternative splicing of U2AF2 in lung adenocarcinoma cells. The alternatively spliced variant of U2AF2 regulates the nuclear export of CAR-Epositive intronless mRNAs, including those encoding Type I interferons.