Detection of Enteric Viruses in Children under Five Years of Age before and after Rotavirus Vaccine Introduction in Manhiça District, Southern Mozambique, 2008–2019
Percina Chirinda,
Filomena Manjate,
Marcelino Garrine,
Augusto Messa,
Nélio Nobela,
Delfino Vubil,
Tacilta Nhampossa,
Sozinho Acácio,
Quique Bassat,
Karen L. Kotloff,
Myron M. Levine,
James P. Nataro,
Jacqueline E. Tate,
Umesh Parashar,
Jason M. Mwenda,
Pedro L. Alonso,
Eva D. João,
Inácio Mandomando
Affiliations
Percina Chirinda
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Filomena Manjate
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Marcelino Garrine
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Augusto Messa
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Nélio Nobela
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Delfino Vubil
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Tacilta Nhampossa
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Sozinho Acácio
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Quique Bassat
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Karen L. Kotloff
Center for Vaccine Development, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Myron M. Levine
Center for Vaccine Development, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
James P. Nataro
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA
Jacqueline E. Tate
Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA
Umesh Parashar
Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA
Jason M. Mwenda
World Health Organization (WHO), Regional Office for Africa, Brazzaville P.O. Box 2465, Congo
Pedro L. Alonso
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Eva D. João
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Inácio Mandomando
Centro de Investigação em Saúde de Manhiça (CISM), Maputo 1929, Mozambique
Enteric viruses are the leading cause of diarrhoea in children p = 0.006) and LSD (25/268, 9.3% vs. 9/430, 2.1%, p p p = 0.002); and sapovirus in MSD (7.1% vs. 1.4%, p = 0.047) and controls (21/475, 4.4% vs. 51/2380, 2.1%, p = 0.004). Norovirus GII, adenovirus 40/41, astrovirus, and sapovirus detection increased in MSD and LSD cases after rotavirus vaccine introduction, supporting the need for continued molecular surveillance for the implementation of appropriate control and prevention measures.
