Communications Biology (Jun 2021)

TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity

  • Xiaojie Yu,
  • Sonya James,
  • James H. Felce,
  • Blanka Kellermayer,
  • David A. Johnston,
  • H. T. Claude Chan,
  • Christine A. Penfold,
  • Jinny Kim,
  • Tatyana Inzhelevskaya,
  • C. Ian Mockridge,
  • Yasunori Watanabe,
  • Max Crispin,
  • Ruth R. French,
  • Patrick J. Duriez,
  • Leon R. Douglas,
  • Martin J. Glennie,
  • Mark S. Cragg

DOI
https://doi.org/10.1038/s42003-021-02309-5
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15

Abstract

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Yu et al examined a panel of both experimental and clinically-relevant TNF agonists in order to advance our understanding of the mechanisms underlying their varying activities and anti-tumor responses. They demonstrated that agonists with greater activity induced higher density receptor clustering and specific super-structures as opposed to simply larger receptor clusters.