Nature Communications (Sep 2017)

Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

  • Yiguo Shen,
  • David Kapfhamer,
  • Angela M. Minnella,
  • Ji-Eun Kim,
  • Seok Joon Won,
  • Yanting Chen,
  • Yong Huang,
  • Ley Hian Low,
  • Stephen M. Massa,
  • Raymond A. Swanson

DOI
https://doi.org/10.1038/s41467-017-00707-0
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Several metabolic factors affect cellular glucose metabolism as well as the innate inflammatory response. Here, the authors show that glucose metabolism regulates pro-inflammatory responses through effects on the cytosolic NADH:NAD+ ratio and the NAD(H)-sensitive transcription co-repressor CtBP.