Nature Communications (Sep 2017)
Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP
Abstract
Several metabolic factors affect cellular glucose metabolism as well as the innate inflammatory response. Here, the authors show that glucose metabolism regulates pro-inflammatory responses through effects on the cytosolic NADH:NAD+ ratio and the NAD(H)-sensitive transcription co-repressor CtBP.