Nature Communications (Aug 2020)
Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
- R. Vatapalli,
- V. Sagar,
- Y. Rodriguez,
- J. C. Zhao,
- K. Unno,
- S. Pamarthy,
- B. Lysy,
- J. Anker,
- H. Han,
- Y. A. Yoo,
- M. Truica,
- Z. R. Chalmers,
- F. Giles,
- J. Yu,
- D. Chakravarti,
- B. Carneiro,
- S. A. Abdulkadir
Affiliations
- R. Vatapalli
- Department of Urology, Northwestern University Feinberg School of Medicine
- V. Sagar
- Department of Urology, Northwestern University Feinberg School of Medicine
- Y. Rodriguez
- Department of Urology, Northwestern University Feinberg School of Medicine
- J. C. Zhao
- Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine
- K. Unno
- Department of Urology, Northwestern University Feinberg School of Medicine
- S. Pamarthy
- Atrin Pharmaceuticals, Pennsylvania Biotechnology Center
- B. Lysy
- Department of Urology, Northwestern University Feinberg School of Medicine
- J. Anker
- Department of Urology, Northwestern University Feinberg School of Medicine
- H. Han
- Department of Urology, Northwestern University Feinberg School of Medicine
- Y. A. Yoo
- Department of Urology, Northwestern University Feinberg School of Medicine
- M. Truica
- Department of Urology, Northwestern University Feinberg School of Medicine
- Z. R. Chalmers
- Department of Urology, Northwestern University Feinberg School of Medicine
- F. Giles
- Developmental Therapeutics Consortium
- J. Yu
- Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine
- D. Chakravarti
- Division of Reproductive Science in Medicine, Department of OB/GYN, Northwestern University Feinberg School of Medicine
- B. Carneiro
- Lifespan Cancer Institute, Division of Hematology/Oncology, Alpert Medical School, Brown University
- S. A. Abdulkadir
- Department of Urology, Northwestern University Feinberg School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-18013-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Histone methyltransferase, DOTL1 is implicated in the pathogenesis of MLL-rearranged leukemia, however, not much is known of its role in prostate cancer (PCa). Here, the authors report that DOTL1 inhibition suppresses both androgen receptor and MYC pathways in a negative feed forward manner to reduce growth of AR-positive PCa.
