Nature Communications (May 2020)
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice
- Stephanie J. Alexopoulos,
- Sing-Young Chen,
- Amanda E. Brandon,
- Joseph M. Salamoun,
- Frances L. Byrne,
- Christopher J. Garcia,
- Martina Beretta,
- Ellen M. Olzomer,
- Divya P. Shah,
- Ashleigh M. Philp,
- Stefan R. Hargett,
- Robert T. Lawrence,
- Brendan Lee,
- James Sligar,
- Pascal Carrive,
- Simon P. Tucker,
- Andrew Philp,
- Carolin Lackner,
- Nigel Turner,
- Gregory J. Cooney,
- Webster L. Santos,
- Kyle L. Hoehn
Affiliations
- Stephanie J. Alexopoulos
- School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Sing-Young Chen
- School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Amanda E. Brandon
- Sydney Medical School, Charles Perkins Centre, University of Sydney
- Joseph M. Salamoun
- Department of Chemistry and Virginia Tech Centre for Drug Discovery, Virginia Tech
- Frances L. Byrne
- School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Christopher J. Garcia
- Department of Chemistry and Virginia Tech Centre for Drug Discovery, Virginia Tech
- Martina Beretta
- School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Ellen M. Olzomer
- School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Divya P. Shah
- School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Ashleigh M. Philp
- Garvan Institute of Medical Research
- Stefan R. Hargett
- Department of Pharmacology, University of Virginia
- Robert T. Lawrence
- Department of Pharmacology, University of Virginia
- Brendan Lee
- Biological Resources Imaging Laboratory, University of New South Wales
- James Sligar
- Garvan Institute of Medical Research
- Pascal Carrive
- Department of Anatomy, School of Medical Sciences, University of New South Wales
- Simon P. Tucker
- Continuum Biosciences Pty Ltd.
- Andrew Philp
- Garvan Institute of Medical Research
- Carolin Lackner
- Institute of Pathology, Medical University of Graz
- Nigel Turner
- Department of Pharmacology, School of Medical Science, University of New South Wales
- Gregory J. Cooney
- Sydney Medical School, Charles Perkins Centre, University of Sydney
- Webster L. Santos
- Department of Chemistry and Virginia Tech Centre for Drug Discovery, Virginia Tech
- Kyle L. Hoehn
- School of Biotechnology and Biomolecular Sciences, University of New South Wales
- DOI
- https://doi.org/10.1038/s41467-020-16298-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Obesity is a global pandemic with limited treatment options. Here, the authors show evidence in mice that the mitochondrial uncoupler BAM15 effectively induces fat loss without affecting food intake or compromising lean body mass.
