Frontiers in Neurology (Jul 2024)
Identification of genetic susceptibility for Chinese migraine with depression using machine learning
- Xingkai An,
- Xingkai An,
- Xingkai An,
- Xingkai An,
- Xingkai An,
- Xingkai An,
- Shanshan Zhao,
- Jie Fang,
- Jie Fang,
- Jie Fang,
- Jie Fang,
- Jie Fang,
- Jie Fang,
- Qingfang Li,
- Cen Yue,
- Cen Yue,
- Cen Yue,
- Cen Yue,
- Cen Yue,
- Cen Yue,
- Chuya Jing,
- Chuya Jing,
- Chuya Jing,
- Chuya Jing,
- Chuya Jing,
- Chuya Jing,
- Yidan Zhang,
- Yidan Zhang,
- Yidan Zhang,
- Yidan Zhang,
- Yidan Zhang,
- Yidan Zhang,
- Jiawei Zhang,
- Jiawei Zhang,
- Jiawei Zhang,
- Jiawei Zhang,
- Jiawei Zhang,
- Jiawei Zhang,
- Jie Zhou,
- Jie Zhou,
- Jie Zhou,
- Jie Zhou,
- Jie Zhou,
- Jie Zhou,
- Caihong Chen,
- Caihong Chen,
- Caihong Chen,
- Caihong Chen,
- Caihong Chen,
- Caihong Chen,
- Hongli Qu,
- Hongli Qu,
- Hongli Qu,
- Hongli Qu,
- Hongli Qu,
- Hongli Qu,
- Qilin Ma,
- Qilin Ma,
- Qilin Ma,
- Qilin Ma,
- Qilin Ma,
- Qilin Ma,
- Qing Lin,
- Qing Lin,
- Qing Lin,
- Qing Lin,
- Qing Lin,
- Qing Lin
Affiliations
- Xingkai An
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Xingkai An
- Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China
- Xingkai An
- Xiamen Key Laboratory of Brain Center, Xiamen, China
- Xingkai An
- Xiamen Medical Quality Control Center for Neurology, Xiamen, China
- Xingkai An
- Fujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, China
- Xingkai An
- Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China
- Shanshan Zhao
- Department of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, China
- Jie Fang
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Jie Fang
- Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China
- Jie Fang
- Xiamen Key Laboratory of Brain Center, Xiamen, China
- Jie Fang
- Xiamen Medical Quality Control Center for Neurology, Xiamen, China
- Jie Fang
- Fujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, China
- Jie Fang
- Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China
- Qingfang Li
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Cen Yue
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Cen Yue
- Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China
- Cen Yue
- Xiamen Key Laboratory of Brain Center, Xiamen, China
- Cen Yue
- Xiamen Medical Quality Control Center for Neurology, Xiamen, China
- Cen Yue
- Fujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, China
- Cen Yue
- Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China
- Chuya Jing
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Chuya Jing
- Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China
- Chuya Jing
- Xiamen Key Laboratory of Brain Center, Xiamen, China
- Chuya Jing
- Xiamen Medical Quality Control Center for Neurology, Xiamen, China
- Chuya Jing
- Fujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, China
- Chuya Jing
- Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China
- Yidan Zhang
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Yidan Zhang
- Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China
- Yidan Zhang
- Xiamen Key Laboratory of Brain Center, Xiamen, China
- Yidan Zhang
- Xiamen Medical Quality Control Center for Neurology, Xiamen, China
- Yidan Zhang
- Fujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, China
- Yidan Zhang
- Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China
- Jiawei Zhang
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Jiawei Zhang
- Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China
- Jiawei Zhang
- Xiamen Key Laboratory of Brain Center, Xiamen, China
- Jiawei Zhang
- Xiamen Medical Quality Control Center for Neurology, Xiamen, China
- Jiawei Zhang
- Fujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, China
- Jiawei Zhang
- Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China
- Jie Zhou
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Jie Zhou
- Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China
- Jie Zhou
- Xiamen Key Laboratory of Brain Center, Xiamen, China
- Jie Zhou
- Xiamen Medical Quality Control Center for Neurology, Xiamen, China
- Jie Zhou
- Fujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, China
- Jie Zhou
- Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China
- Caihong Chen
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Caihong Chen
- Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China
- Caihong Chen
- Xiamen Key Laboratory of Brain Center, Xiamen, China
- Caihong Chen
- Xiamen Medical Quality Control Center for Neurology, Xiamen, China
- Caihong Chen
- Fujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, China
- Caihong Chen
- Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China
- Hongli Qu
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Hongli Qu
- Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China
- Hongli Qu
- Xiamen Key Laboratory of Brain Center, Xiamen, China
- Hongli Qu
- Xiamen Medical Quality Control Center for Neurology, Xiamen, China
- Hongli Qu
- Fujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, China
- Hongli Qu
- Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China
- Qilin Ma
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Qilin Ma
- Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China
- Qilin Ma
- Xiamen Key Laboratory of Brain Center, Xiamen, China
- Qilin Ma
- Xiamen Medical Quality Control Center for Neurology, Xiamen, China
- Qilin Ma
- Fujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, China
- Qilin Ma
- Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China
- Qing Lin
- Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Qing Lin
- Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China
- Qing Lin
- Xiamen Key Laboratory of Brain Center, Xiamen, China
- Qing Lin
- Xiamen Medical Quality Control Center for Neurology, Xiamen, China
- Qing Lin
- Fujian Provincial Clinical Research Center for Brain Diseases, Fuzhou, China
- Qing Lin
- Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China
- DOI
- https://doi.org/10.3389/fneur.2024.1418529
- Journal volume & issue
-
Vol. 15
Abstract
BackgroundMigraine is a common primary headache that has a significant impact on patients’ quality of life. The co-occurrence of migraine and depression is frequent, resulting in more complex symptoms and a poorer prognosis. The evidence suggests that depression and migraine comorbidity share a polygenic genetic background.ObjectiveThe aim of this study is to identify related genetic variants that contribute to genetic susceptibility to migraine with and without depression in a Chinese cohort.MethodsIn this case-control study, 263 individuals with migraines and 223 race-matched controls were included. Eight genetic polymorphism loci selected from the GWAS were genotyped using Sequenom’s MALDI-TOF iPLEX platform.ResultsIn univariate analysis, ANKDD1B rs904743 showed significant differences in genotype and allele distribution between migraineurs and controls. Furthermore, a machine learning approach was used to perform multivariate analysis. The results of the Random Forest algorithm indicated that ANKDD1B rs904743 was a significant risk factor for migraine susceptibility in China. Additionally, subgroup analysis by the Boruta algorithm showed a significant association between this SNP and migraine comorbid depression. Migraineurs with depression have been observed to have worse scores on the Beck Anxiety Inventory (BAI) and the Migraine Disability Assessment Scale (MIDAS).ConclusionThe study indicates that there is an association between ANKDD1B rs904743 and susceptibility to migraine with and without depression in Chinese patients.
Keywords