Synthesis of Imine Congeners of Resveratrol and Evaluation of Their Anti-Platelet Activity
Mohammad Bigdeli,
Maryam Sabbaghan,
Marjan Esfahanizadeh,
Farzad Kobarfard,
Sara Vitalini,
Marcello Iriti,
Javad Sharifi-Rad
Affiliations
Mohammad Bigdeli
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Islamic Azad University-Pharmaceutical Sciences Branch (IAUPS), Tehran 11369, Iran
Maryam Sabbaghan
Chemistry Department, Faculty of Sciences, Shahid Rajaee Teacher Training University, Lavizan 16785-163, Tehran, Iran
Marjan Esfahanizadeh
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 14155-6153, Iran
Farzad Kobarfard
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 14155-6153, Iran
Sara Vitalini
Department of Agricultural and Environmental Sciences, Milan State University Via G. Celoria 2, 20133 Milan, Italy
Marcello Iriti
Department of Agricultural and Environmental Sciences, Milan State University Via G. Celoria 2, 20133 Milan, Italy
Javad Sharifi-Rad
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615585, Iran
Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a cardioprotective phytochemical occurring in many plant products. In this study, a new series of imine congeners of resveratrol has been synthesized in which the imine moiety replaced the double bond in the structure of resveratrol. In addition, the in vitro antiplatelet activity of these resveratrol derivatives has been evaluated against adenosine diphosphate (ADP), arachidonic acid (AA), and collagen as platelet aggregation inducers. In general, the synthesized compounds were active as antiplatelet agents, and, therefore, the imine functional group may be considered as an effective replacement for a double bond in resveratrol for developing new and promising antiplatelet drugs.
