A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

Antonio E. Muruato; Camila R. Fontes-Garfias; Ping Ren; Mariano A. Garcia-Blanco; Vineet D. Menachery; Xuping Xie; Pei-Yong Shi

doi:10.1038/s41467-020-17892-0

Nature Communications (Aug 2020)

A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation

Antonio E. Muruato,
Camila R. Fontes-Garfias,
Ping Ren,
Mariano A. Garcia-Blanco,
Vineet D. Menachery,
Xuping Xie,
Pei-Yong Shi

Affiliations

Antonio E. Muruato: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
Camila R. Fontes-Garfias: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
Ping Ren: Department of Pathology, University of Texas Medical Branch
Mariano A. Garcia-Blanco: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
Vineet D. Menachery: Department of Microbiology and Immunology, University of Texas Medical Branch
Xuping Xie: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
Pei-Yong Shi: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch

DOI: https://doi.org/10.1038/s41467-020-17892-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 6

Abstract

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Neutralizing antibody titers in SARS-CoV-2 infected or vaccinated people are an important measure for vaccine development and public health decision-making. Here, the authors develop a fluorescence based SARS-CoV-2 assay to determine neutralizing antibody titers in COVID-19 patient sera in a high throughput set-up.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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