Stroke prevention in patients with atrial fibrillation and comorbidities

Abstract

In the article questions of prevention of stroke, including repeated ones, are considered. The choice of anticoagulant therapy is discussed in patients with atrial fibrillation and a number of concomitant diseases - coronary artery disease, diabetes mellitus, chronic kidney disease, chronic heart failure. The data of subanalyses of a randomized clinical trial of ARISTOTLE are presented, indicating a high profile of efficacy and safety of the new oral anticoagulant apixaban in these categories of patients.

Keywords

• atrial fibrillation
• arterial hypertension
• coronary artery disease
• diabetes mellitus
• chronic kidney disease
• chronic heart failure
• anticoagulant therapy
• apixaban