Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis

Abstract

Current standard therapies for toxoplasmic encephalitis often cause severe adverse events. A 57-year-old HIV-positive man in Japan who had toxoplasmic encephalitis but was intolerant to trimethoprim/sulfamethoxazole, pyrimethamine, sulfadiazine, and atovaquone was successfully treated with the combination of clindamycin and azithromycin. This drug combination can be an alternative treatment for this condition.

Keywords

• Toxoplasmic encephalitis
• azithromycin
• clindamycin
• alternative treatment
• parasites
• HIV