How Effective are Nano-Based Dressings in Diabetic Wound Healing? A Comprehensive Review of Literature

Abstract

Feng Wang,1 Wenyao Zhang,1 Hao Li,1 Xiaonan Chen,1 Sining Feng,1 Ziqing Mei2 1Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 100081, People’s Republic of China; 2School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, People’s Republic of ChinaCorrespondence: Ziqing Mei, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, People’s Republic of China, Email [email protected]: Chronic wound caused by diabetes is an important cause of disability and seriously affects the quality of life of patients. Therefore, it is of great clinical significance to develop a wound dressing that can accelerate the healing of diabetic wounds. Nanoparticles have great advantages in promoting diabetic wound healing due to their antibacterial properties, low cytotoxicity, good biocompatibility and drug delivery ability. Adding nanoparticles to the dressing matrix and using nanoparticles to deliver drugs and cytokines to promote wound healing has proven to be effective. This review will focus on the effects of diabetes on wound healing, introduce the properties, preparation methods and action mechanism of nanoparticles in wound healing, and describe the effects and application status of various nanoparticle-loaded dressings in diabetes-related chronic wound healing.Keywords: diabetic wound healing, nanoparticles, antibacterial, low cytotoxicity, good biocompatibility, drug delivery

Keywords

• diabetic wound healing
• nanoparticles
• antibacterial
• low cytotoxicity
• good biocompatibility
• drug delivery