Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination

Greg J. Duncan; Sohrab B. Manesh; Brett J. Hilton; Peggy Assinck; Jie Liu; Aaron Moulson; Jason R. Plemel; Wolfram Tetzlaff

doi:10.1038/s41467-018-05473-1

Nature Communications (Aug 2018)

Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination

Greg J. Duncan,
Sohrab B. Manesh,
Brett J. Hilton,
Peggy Assinck,
Jie Liu,
Aaron Moulson,
Jason R. Plemel,
Wolfram Tetzlaff

Affiliations

Greg J. Duncan: International Collaboration on Repair Discoveries (ICORD), University of British Columbia (UBC)
Sohrab B. Manesh: International Collaboration on Repair Discoveries (ICORD), University of British Columbia (UBC)
Brett J. Hilton: International Collaboration on Repair Discoveries (ICORD), University of British Columbia (UBC)
Peggy Assinck: International Collaboration on Repair Discoveries (ICORD), University of British Columbia (UBC)
Jie Liu: International Collaboration on Repair Discoveries (ICORD), University of British Columbia (UBC)
Aaron Moulson: International Collaboration on Repair Discoveries (ICORD), University of British Columbia (UBC)
Jason R. Plemel: The Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary
Wolfram Tetzlaff: International Collaboration on Repair Discoveries (ICORD), University of British Columbia (UBC)

DOI: https://doi.org/10.1038/s41467-018-05473-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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The contribution of oligodendrocytes to remyelination in functional recovery after spinal cord injury is not fully understood. Here, the authors show that oligodendrocyte progenitor cell differentiation is not required for functional recovery after spinal cord injury in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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