RHD and RHCE genes polymorphism: literature review

Abstract

The article provides a literature review about RHD and RHCE polymorphisms which encode different RhD and RhC antigen variants. The data about genes RHD and RHCE polymorphisms, RhD weak types, RhD partial types and RhC variants in Russians is presented for the first time. The molecular and serological characteristics of rare RhD and RhC antigens are summarized. The role of serological and molecular methods in Rhesus system antigens identifying is shown.

Keywords

• rhesus system
• antigen rhd types
• antigen rhc types
• rh-phenotypes
• problem of determining rh-affiliation
• difficult to determine blood group
• serological method
• genotyping