Neonatal Cerebral Sinovenous Thrombosis and the Main Perinatal Risk Factors—A Retrospective Unicentric Study
Catalina Filip,
Gabriela Ildiko Zonda,
Ingrid-Andrada Vasilache,
Ioana Sadiye Scripcariu,
Petronela Vicoveanu,
Vlad Dima,
Demetra Socolov,
Luminita Paduraru
Affiliations
Catalina Filip
Saint Spiridon University Hospital, Vascular Surgery Clinic, Independence Boulevard No. 1, 700111 Iasi, Romania
Gabriela Ildiko Zonda
Division of Neonatology, Department of Mother and Child Care, “Grigore T. Popa” University of Medicine and Pharmacy, 700111 Iasi, Romania
Ingrid-Andrada Vasilache
Division of Obstetrics and Gynecology, Department of Mother and Child Care, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Ioana Sadiye Scripcariu
Division of Obstetrics and Gynecology, Department of Mother and Child Care, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Petronela Vicoveanu
Division of Obstetrics and Gynecology, Department of Mother and Child Care, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Vlad Dima
Department of Obstetrics, Gynecology and Neonatology, Filantropia Clinical Hospital, 11-13 Ion Mihalache Blv., Sector 1, 011171 Bucharest, Romania
Demetra Socolov
Division of Obstetrics and Gynecology, Department of Mother and Child Care, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Luminita Paduraru
Division of Neonatology, Department of Mother and Child Care, “Grigore T. Popa” University of Medicine and Pharmacy, 700111 Iasi, Romania
(1) Background: Neonatal cerebral sinovenous thrombosis (CSVT) is a rare disorder, associated with long-term neurological sequelae. The aim of this study was to retrospectively evaluate the most commonly encountered perinatal risk factors for this disease in a cohort of newborns from Romania. (2) Methods: The medical records of neonatal CSVT patients treated between January 2017 and December 2021 were descriptively assessed. (3) Results: The study included nine neonates, five males (55.56%) and four females (44.44%), who were born at term. The most commonly presented clinical manifestations were feeding difficulties, lethargy, respiratory distress, loss of consciousness, and seizures. Maternal-inherited thrombophilia, male sex, complicated delivery, perinatal asphyxia, and mechanical ventilation were frequently identified as potential risk factors for developing CSVT. The lesions were more frequently localized in the superior sagittal sinus (n = 7; 77.78%), followed by the transverse (n = 4; 44.44%), sigmoid (n = 2; 22.22%), and cavernous (n = 1; 11.11%) sinuses. Low-molecular-weight heparin was administered to all patients, and two of them died from thrombotic complications. (4) Conclusions: Recognition of potential risk factors and a prompt diagnosis of neonatal CSVT could lead to better patient management and to a reduction of severe complications.
