Nature Communications (Jun 2021)
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation
- Fuqing Hu,
- Da Song,
- Yumeng Yan,
- Changsheng Huang,
- Chentao Shen,
- Jingqin Lan,
- Yaqi Chen,
- Anyi Liu,
- Qi Wu,
- Li Sun,
- Feng Xu,
- Fayong Hu,
- Lisheng Chen,
- Xuelai Luo,
- Yongdong Feng,
- Shengyou Huang,
- Junbo Hu,
- Guihua Wang
Affiliations
- Fuqing Hu
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Da Song
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Yumeng Yan
- School of Physics, Huazhong University of Science and Technology
- Changsheng Huang
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Chentao Shen
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Jingqin Lan
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Yaqi Chen
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Anyi Liu
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Qi Wu
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Li Sun
- Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology
- Feng Xu
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Fayong Hu
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Lisheng Chen
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Xuelai Luo
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Yongdong Feng
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Shengyou Huang
- School of Physics, Huazhong University of Science and Technology
- Junbo Hu
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- Guihua Wang
- GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-021-23923-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
IL-6 is an important cytokine in the tumour microenvironment, but its role in regulating autophagy in cancer cells is unclear. Here the authors show that IL-6 activates autophagy in colorectal cancer through the interaction between JAK2 and autophagy regulator, BECN1, which leads to chemotherapeutic resistance.
