Inhaled D-Limonene minimizes acute lung injury and reduces oxidative stress induced by smoke in rats

Hericalizandra Santa Rosa Santana; Fernanda Oliveira de Carvalho; Danillo Menezes dos Santos; Eric Aian Pereira da Silva; Érika Ramos Silva; Saravanan Shanmugam; Luana Heimfarth; Paula Santos Nunes; Ana Mara de Oliveira e Silva; Adriano Antunes de Souza Araújo; Ricardo Luiz Cavalcanti de Albuquerque; Márcio Roberto Viana dos Santos

Phytomedicine Plus (Aug 2022)

Inhaled D-Limonene minimizes acute lung injury and reduces oxidative stress induced by smoke in rats

Hericalizandra Santa Rosa Santana,
Fernanda Oliveira de Carvalho,
Danillo Menezes dos Santos,
Eric Aian Pereira da Silva,
Érika Ramos Silva,
Saravanan Shanmugam,
Luana Heimfarth,
Paula Santos Nunes,
Ana Mara de Oliveira e Silva,
Adriano Antunes de Souza Araújo,
Ricardo Luiz Cavalcanti de Albuquerque,
Márcio Roberto Viana dos Santos

Affiliations

Hericalizandra Santa Rosa Santana: Health Sciences Graduate Program, Federal University of Sergipe (UFS), Cláudio Batista St, s/n, Sanatório, Aracaju-SE, Brazil
Fernanda Oliveira de Carvalho: Health Sciences Graduate Program, Federal University of Sergipe (UFS), Cláudio Batista St, s/n, Sanatório, Aracaju-SE, Brazil
Danillo Menezes dos Santos: Health Sciences Graduate Program, Federal University of Sergipe (UFS), Cláudio Batista St, s/n, Sanatório, Aracaju-SE, Brazil; Department of Physiology, Federal University of Sergipe (UFS), Marechal Rondom Avenue s/n, São Cristóvão, SE, Brazil
Eric Aian Pereira da Silva: Biotechnology Graduate Program - RENORBIO, Federal University of Sergipe (UFS), Marechal Rondom Avenue s/n, São Cristóvão, SE, Brazil; Department of Physiology, Federal University of Sergipe (UFS), Marechal Rondom Avenue s/n, São Cristóvão, SE, Brazil
Érika Ramos Silva: Department of Physiotherapy, Federal University of Sergipe (UFS), Gov. Marcelo Deda Avenue, 300, Lagarto, SE, Brazil
Saravanan Shanmugam: Health Sciences Graduate Program, Federal University of Sergipe (UFS), Cláudio Batista St, s/n, Sanatório, Aracaju-SE, Brazil
Luana Heimfarth: Department of Physiology, Federal University of Sergipe (UFS), Marechal Rondom Avenue s/n, São Cristóvão, SE, Brazil
Paula Santos Nunes: Health Sciences Graduate Program, Federal University of Sergipe (UFS), Cláudio Batista St, s/n, Sanatório, Aracaju-SE, Brazil; Department of Morphology, Federal University of Sergipe (UFS), Marechal Rondom Avenue s/n, São Cristóvão, SE, Brazil
Ana Mara de Oliveira e Silva: Health Sciences Graduate Program, Federal University of Sergipe (UFS), Cláudio Batista St, s/n, Sanatório, Aracaju-SE, Brazil; Department of Nutrition, Federal University of Sergipe (UFS), Marechal Rondom Avenue s/n, São Cristóvão, SE, Brazil
Adriano Antunes de Souza Araújo: Health Sciences Graduate Program, Federal University of Sergipe (UFS), Cláudio Batista St, s/n, Sanatório, Aracaju-SE, Brazil; Department of Pharmacy, Federal University of Sergipe (UFS), Marechal Rondom Avenue s/n, São Cristóvão, SE, Brazil
Ricardo Luiz Cavalcanti de Albuquerque: Sergipe Institute of Technology and Research, Tiradentes University (UNIT), Murilo Dantas Avenue, 300, Farolândia, Aracaju, SE, Brazil
Márcio Roberto Viana dos Santos: Health Sciences Graduate Program, Federal University of Sergipe (UFS), Cláudio Batista St, s/n, Sanatório, Aracaju-SE, Brazil; Department of Physiology, Federal University of Sergipe (UFS), Marechal Rondom Avenue s/n, São Cristóvão, SE, Brazil; Corresponding author.

Journal volume & issue: Vol. 2, no. 3
p. 100308

Abstract

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Background: Despite some advances in the discovery of novel therapies, smoke inhalation injury remains a difficult to treat critical health issue due to its physiopathological complexity. Natural products, such as d-limonene (LIM), are becoming an important potential source of new treatments in many health problems. LIM has been shown to have antioxidant, anti-inflammatory and protective effects in respect of several diseases, including respiratory conditions. Objective: The aim of this study was to evaluate the effects of inhaled LIM on acute smoke-induced lung injury in rats. Methods: Thirty minutes after smoke inhalation, adult male Wistar rats were treated with vehicle or LIM (0.01 mg/kg) for 30 min. Blood samples, and the liver, lungs, and trachea were collected for analysis. Results: The results showed that LIM minimized the injuries, reducing oxidative and inflammatory damage by improving catalase (CAT) (p < 0.05), and superoxide dismutase (SOD) activities (trachea: p < 0.01; lung: p < 0.05) and reducing interleukin-1 beta (IL-1β) level (p < 0.01) caused by smoke inhalation. LIM was also able to ameliorate damage in both trachea and lung tissues. Conclusions: The results indicate that LIM has a beneficial effect on lung injury, mainly by reducing oxidative stress, anti-inflammatory response and tissue damage.

Published in Phytomedicine Plus

ISSN: 2667-0313 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Other systems of medicine
Website: https://www.journals.elsevier.com/phytomedicine-plus/

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