Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience
Łukasz Nyk,
Hubert Kamecki,
Wojciech Krajewski,
Bartosz Małkiewicz,
Tomasz Szydełko,
Markiian Kubis,
Marcin Słojewski,
Piotr Kryst,
Sławomir Poletajew,
Wojciech Malewski
Affiliations
Łukasz Nyk
Second Department of Urology, Centre of Postgraduate Medical Education, 01-809 Warsaw, Poland
Hubert Kamecki
Second Department of Urology, Centre of Postgraduate Medical Education, 01-809 Warsaw, Poland
Wojciech Krajewski
Department of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wrocław Medical University, 50-556 Wrocław, Poland
Bartosz Małkiewicz
Department of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wrocław Medical University, 50-556 Wrocław, Poland
Tomasz Szydełko
Department of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wrocław Medical University, 50-556 Wrocław, Poland
Markiian Kubis
Department of Urology and Urological Oncology, Pomeranian Medical University, 70-111 Szczecin, Poland
Marcin Słojewski
Department of Urology and Urological Oncology, Pomeranian Medical University, 70-111 Szczecin, Poland
Piotr Kryst
Second Department of Urology, Centre of Postgraduate Medical Education, 01-809 Warsaw, Poland
Sławomir Poletajew
Second Department of Urology, Centre of Postgraduate Medical Education, 01-809 Warsaw, Poland
Wojciech Malewski
Second Department of Urology, Centre of Postgraduate Medical Education, 01-809 Warsaw, Poland
We aimed to retrospectively analyze consecutive prostate cancer patients diagnosed with biochemical or clinical recurrence after local treatment with curative intent, with no evidence of distant metastases, who underwent positron emission tomography/computed tomography (PET/CT) with choline followed by salvage lymph node dissection (SLND) in three academic centers between 2013 and 2020. A total of 27 men were included in the analyses. Sensitivity, specificity, positive and negative predictive values, and accuracy of choline-PET/CT in predicting pathology-proven lymph node involvement were 75%, 43%, 79%, 38% and 67% on per-patient and 70%, 86%, 80%, 78%, and 79% on per-site analyses, respectively, with the differences in specificity and NPV between per-patient and per-site analyses being statistically significant (p = 0.03 and 0.04, respectively). The study provides further insight into the role of preoperative choline-PET/CT in patients undergoing SLND for recurrent PC.