Data on immunogenicity and reactogenicity to COVID-19 vaccination among patients receiving maintenance dialysis
Hristos Karakizlis,
Christian Nahrgang,
Kevin Strecker,
Jiangping Chen,
Mostafa Aly,
Heiko Slanina,
Christian G. Schüttler,
Isla Esso,
Martin Wolter,
Darina Todorova,
Sönke Jessen,
Andrea Adamik,
Claudio Ronco,
Werner Seeger,
Rolf Weimer,
Martina Sester,
Horst-Walter Birk,
Faeq Husain-Syed
Affiliations
Hristos Karakizlis
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany; Corresponding authors.
Christian Nahrgang
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany
Kevin Strecker
AID GmbH, Ebinger Straße 4, Strassberg 72479, Germany
Jiangping Chen
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany
Mostafa Aly
Transplantation Immunology, Institute of Immunology, University Hospital Heidelberg, Im Neuenheimer Feld 305, Heidelberg 69120, Germany; Nephrology Unit, Internal Medicine Department, Assiut University, Governorate 71515, Assiut, Egypt
Heiko Slanina
Institute of Medical Virology, Justus-Liebig-University Giessen, Schubertstraße 81, Giessen 35392, Germany
Christian G. Schüttler
Institute of Medical Virology, Justus-Liebig-University Giessen, Schubertstraße 81, Giessen 35392, Germany
Isla Esso
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany
Martin Wolter
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany
Darina Todorova
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany
Sönke Jessen
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany
Andrea Adamik
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany
Claudio Ronco
Department of Nephrology, Dialysis and Transplantation, International Renal Research Institute of Vicenza, San Bortolo Hospital, Via Rodolfi, Vicenza 37–36100, Italy; Department of Medicine (DIMED), Università di Padova, Via Giustiniani, Padua 2–35128, Italy
Werner Seeger
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany; Member of the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Klinikstraße 33, Giessen 35392, Germany; Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Ludwigstraße 43, Bad Nauheim 61231, Germany
Rolf Weimer
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany
Martina Sester
Department of Transplant and Infection Immunology, Saarland University, Kirrberger Straße, Homburg 66421, Germany
Horst-Walter Birk
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany
Faeq Husain-Syed
Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Klinikstraße 33, Giessen 35392, Germany; Department of Nephrology, Dialysis and Transplantation, International Renal Research Institute of Vicenza, San Bortolo Hospital, Via Rodolfi, Vicenza 37–36100, Italy; Corresponding authors.
Compared with the general population, patients receiving maintenance dialysis are at increased risk for morbidity and mortality associated with coronavirus disease 2019 (COVID-19). Currently, data on severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)-specific immunity post-vaccination in patients on maintenance dialysis are scarce given that the effectiveness of the vaccines has not been explicitly tested in this population due to their common exclusion from SARS-CoV-2 vaccination trials. We herein present data of the specific cellular (interferon-γ and interleukin-2 ELISpot assays) and humoral immune responses (dot plot array and chemiluminescent microparticle immunoassay) at 4 weeks and 6 weeks following a single dose or a complete homologous dual dose SARS-CoV-2 vaccine regimen in 60 adult patients on maintenance dialysis (six with a history of COVID-19). The data was produced in a framework of a project focused on a) quantifying the immune response after full vaccination, b) evaluating the short-term durability of immune response, and c) examining the reactogenicity of SARS-CoV-2 vaccine regimens in patients on maintenance dialysis.
