iScience (May 2023)
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia
- Yu-Han H. Hsu,
- Greta Pintacuda,
- Ruize Liu,
- Eugeniu Nacu,
- April Kim,
- Kalliopi Tsafou,
- Natalie Petrossian,
- William Crotty,
- Jung Min Suh,
- Jackson Riseman,
- Jacqueline M. Martin,
- Julia C. Biagini,
- Daya Mena,
- Joshua K.T. Ching,
- Edyta Malolepsza,
- Taibo Li,
- Tarjinder Singh,
- Tian Ge,
- Shawn B. Egri,
- Benjamin Tanenbaum,
- Caroline R. Stanclift,
- Annie M. Apffel,
- Steven A. Carr,
- Monica Schenone,
- Jake Jaffe,
- Nadine Fornelos,
- Hailiang Huang,
- Kevin C. Eggan,
- Kasper Lage,
- Stephan Ripke,
- Benjamin M. Neale,
- Aiden Corvin,
- James T.R. Walters,
- Kai-How Farh,
- Peter A. Holmans,
- Phil Lee,
- Brendan Bulik-Sullivan,
- David A. Collier,
- Hailiang Huang,
- Tune H. Pers,
- Ingrid Agartz,
- Esben Agerbo,
- Margot Albus,
- Madeline Alexander,
- Farooq Amin,
- Silviu A. Bacanu,
- Martin Begemann,
- Richard A. Belliveau, Jr.,
- Judit Bene,
- Sarah E. Bergen,
- Elizabeth Bevilacqua,
- Tim B. Bigdeli,
- Donald W. Black,
- Richard Bruggeman,
- Nancy G. Buccola,
- Randy L. Buckner,
- William Byerley,
- Wiepke Cahn,
- Guiqing Cai,
- Dominique Campion,
- Rita M. Cantor,
- Vaughan J. Carr,
- Noa Carrera,
- Stanley V. Catts,
- Kimberley D. Chambert,
- Raymond C.K. Chan,
- Ronald Y.L. Chan,
- Eric Y.H. Chen,
- Wei Cheng,
- Eric FC. Cheung,
- Siow Ann Chong,
- C. Robert Cloninger,
- David Cohen,
- Nadine Cohen,
- Paul Cormican,
- Nick Craddock,
- James J. Crowley,
- David Curtis,
- Michael Davidson,
- Kenneth L. Davis,
- Franziska Degenhardt,
- Jurgen Del Favero,
- Ditte Demontis,
- Dimitris Dikeos,
- Timothy Dinan,
- Srdjan Djurovic,
- Gary Donohoe,
- Elodie Drapeau,
- Jubao Duan,
- Frank Dudbridge,
- Naser Durmishi,
- Peter Eichhammer,
- Johan Eriksson,
- Valentina Escott-Price,
- Laurent Essioux,
- Ayman H. Fanous,
- Martilias S. Farrell,
- Josef Frank,
- Lude Franke,
- Robert Freedman,
- Nelson B. Freimer,
- Marion Friedl,
- Joseph I. Friedman,
- Menachem Fromer,
- Giulio Genovese,
- Lyudmila Georgieva,
- Ina Giegling,
- Paola Giusti-Rodríguez,
- Stephanie Godard,
- Jacqueline I. Goldstein,
- Vera Golimbet,
- Srihari Gopal,
- Jacob Gratten,
- Lieuwe de Haan,
- Christian Hammer,
- Marian L. Hamshere,
- Mark Hansen,
- Thomas Hansen,
- Vahram Haroutunian,
- Annette M. Hartmann,
- Frans A. Henskens,
- Stefan Herms,
- Joel N. Hirschhorn,
- Per Hoffmann,
- Andrea Hofman,
- Mads V. Hollegaard,
- David M. Hougaard,
- Masashi Ikeda,
- Inge Joa,
- Antonio Julià,
- René S. Kahn,
- Luba Kalaydjieva,
- Sena Karachanak-Yankova,
- Juha Karjalainen,
- David Kavanagh,
- Matthew C. Keller,
- James L. Kennedy,
- Andrey Khrunin,
- Yunjung Kim,
- Janis Klovins,
- James A. Knowles,
- Bettina Konte,
- Vaidutis Kucinskas,
- Zita Ausrele Kucinskiene,
- Hana Kuzelova-Ptackova,
- Anna K. Kähler,
- Claudine Laurent,
- Jimmy Lee,
- S. Hong Lee,
- Sophie E. Legge,
- Bernard Lerer,
- Miaoxin Li,
- Tao Li,
- Kung-Yee Liang,
- Jeffrey Lieberman,
- Svetlana Limborska,
- Carmel M. Loughland,
- Jan Lubinski,
- Jouko Lönnqvist,
- Milan Macek,
- Patrik K.E. Magnusson,
- Brion S. Maher,
- Wolfgang Maier,
- Jacques Mallet,
- Sara Marsal,
- Manuel Mattheisen,
- Morten Mattingsdal,
- Robert W. McCarley,
- Colm McDonald,
- Andrew M. McIntosh,
- Sandra Meier,
- Carin J. Meijer,
- Bela Melegh,
- Ingrid Melle,
- Raquelle I. Mesholam-Gately,
- Andres Metspalu,
- Patricia T. Michie,
- Lili Milani,
- Vihra Milanova,
- Younes Mokrab,
- Derek W. Morris,
- Ole Mors,
- Kieran C. Murphy,
- Robin M. Murray,
- Inez Myin-Germeys,
- Bertram Müller-Myhsok,
- Mari Nelis,
- Igor Nenadic,
- Deborah A. Nertney,
- Gerald Nestadt,
- Kristin K. Nicodemus,
- Liene Nikitina-Zake,
- Laura Nisenbaum,
- Annelie Nordin,
- Eadbhard O'Callaghan,
- Colm O'Dushlaine,
- F. Anthony O'Neill,
- Sang-Yun Oh,
- Ann Olincy,
- Line Olsen,
- Jim Van Os,
- Christos Pantelis,
- George N. Papadimitriou,
- Sergi Papiol,
- Elena Parkhomenko,
- Michele T. Pato,
- Tiina Paunio,
- Milica Pejovic-Milovancevic,
- Diana O. Perkins,
- Olli Pietiläinen,
- Jonathan Pimm,
- Andrew J. Pocklington,
- John Powell,
- Alkes Price,
- Ann E. Pulver,
- Shaun M. Purcell,
- Digby Quested,
- Henrik B. Rasmussen,
- Abraham Reichenberg,
- Mark A. Reimers,
- Alexander L. Richards,
- Joshua L. Roffman,
- Panos Roussos,
- Douglas M. Ruderfer,
- Veikko Salomaa,
- Alan R. Sanders,
- Ulrich Schall,
- Christian R. Schubert,
- Thomas G. Schulze,
- Sibylle G. Schwab,
- Edward M. Scolnick,
- Rodney J. Scott,
- Larry J. Seidman,
- Jianxin Shi,
- Engilbert Sigurdsson,
- Teimuraz Silagadze,
- Jeremy M. Silverman,
- Kang Sim,
- Petr Slominsky,
- Jordan W. Smoller,
- Hon-Cheong So,
- Chris C.A. Spencer,
- Eli A. Stahl,
- Hreinn Stefansson,
- Stacy Steinberg,
- Elisabeth Stogmann,
- Richard E. Straub,
- Eric Strengman,
- Jana Strohmaier,
- T Scott Stroup,
- Mythily Subramaniam,
- Jaana Suvisaari,
- Dragan M. Svrakic,
- Jin P. Szatkiewicz,
- Erik Söderman,
- Srinivas Thirumalai,
- Draga Toncheva,
- Sarah Tosato,
- Juha Veijola,
- John Waddington,
- Dermot Walsh,
- Dai Wang,
- Qiang Wang,
- Bradley T. Webb,
- Mark Weiser,
- Dieter B. Wildenauer,
- Nigel M. Williams,
- Stephanie Williams,
- Stephanie H. Witt,
- Aaron R. Wolen,
- Emily H.M. Wong,
- Brandon K. Wormley,
- Hualin Simon Xi,
- Clement C. Zai,
- Xuebin Zheng,
- Fritz Zimprich,
- Naomi R. Wray,
- Kari Stefansson,
- Peter M. Visscher,
- Rolf Adolfsson,
- Ole A. Andreassen,
- Douglas H.R. Blackwood,
- Elvira Bramon,
- Joseph D. Buxbaum,
- Anders D. Børglum,
- Sven Cichon,
- Ariel Darvasi,
- Enrico Domenici,
- Hannelore Ehrenreich,
- Tõnu Esko,
- Pablo V. Gejman,
- Michael Gill,
- Hugh Gurling,
- Christina M. Hultman,
- Nakao Iwata,
- Assen V. Jablensky,
- Erik G. Jönsson,
- Kenneth S. Kendler,
- George Kirov,
- Jo Knight,
- Todd Lencz,
- Douglas F. Levinson,
- Qingqin S. Li,
- Jianjun Liu,
- Anil K. Malhotra,
- Steven A. McCarroll,
- Andrew McQuillin,
- Jennifer L. Moran,
- Preben B. Mortensen,
- Bryan J. Mowry,
- Markus M. Nöthen,
- Roel A. Ophoff,
- Michael J. Owen,
- Aarno Palotie,
- Carlos N. Pato,
- Tracey L. Petryshen,
- Danielle Posthuma,
- Marcella Rietschel,
- Brien P. Riley,
- Dan Rujescu,
- Pak C. Sham,
- Pamela Sklar,
- David St Clair,
- Daniel R. Weinberger,
- Jens R. Wendland,
- Thomas Werge,
- Mark J. Daly,
- Patrick F. Sullivan,
- Michael C. O'Donovan,
- Hailiang Huang,
- Shengying Qin,
- Akira Sawa,
- Sibylle G. Schwab,
- Rene Kahn,
- Kyung Sue Hong,
- Wenzhao Shi,
- Ming Tsuang,
- Masanari Itokawa,
- Gang Feng,
- Jianjun Liu,
- Stephen J. Glatt,
- Nakao Iwata,
- Masashi Ikeda,
- Xiancang Ma,
- Jimmy Lee,
- Jinsong Tang,
- Yunfeng Ruan,
- Ruize Liu,
- Feng Zhu,
- Yasue Horiuchi,
- Byung Dae Lee,
- Eun-Jeong Joo,
- Woojae Myung,
- Kyooseob Ha,
- Hong-Hee Won,
- Ji Hyung Baek,
- Young Chul Chung,
- Sung-Wan Kim,
- Dieter B. Wildenauer,
- Agung Kusumawardhani,
- Wei J. Chen,
- Hai-Gwo Hwu,
- Kang Sim,
- Akitoyo Hishimoto,
- Ikuo Otsuka,
- Ichiro Sora,
- Tomoko Toyota,
- Takeo Yoshikawa,
- Hiroshi Kunugi,
- Kotaro Hattori,
- Sayuri Ishiwata,
- Shusuke Numata,
- Tetsuro Ohmori,
- Makoto Arai,
- Yuji Ozeki,
- Kumiko Fujii,
- Se Joo Kim,
- Heon-Jeong Lee,
- Yong Min Ahn,
- Se Hyun Kim,
- Kazufumi Akiyama,
- Kazutaka Shimoda,
- Makoto Kinoshita
Affiliations
- Yu-Han H. Hsu
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
- Greta Pintacuda
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
- Ruize Liu
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
- Eugeniu Nacu
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
- April Kim
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA
- Kalliopi Tsafou
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Natalie Petrossian
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- William Crotty
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Jung Min Suh
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Jackson Riseman
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Jacqueline M. Martin
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Julia C. Biagini
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Daya Mena
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Joshua K.T. Ching
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Edyta Malolepsza
- Genomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Taibo Li
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Tarjinder Singh
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
- Tian Ge
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
- Shawn B. Egri
- Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Benjamin Tanenbaum
- Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Caroline R. Stanclift
- Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Annie M. Apffel
- Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Steven A. Carr
- Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Monica Schenone
- Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Jake Jaffe
- Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Nadine Fornelos
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
- Hailiang Huang
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
- Kevin C. Eggan
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Corresponding author
- Kasper Lage
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA; Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen, 4000 Roskilde, Denmark; Corresponding author
- Stephan Ripke
- Benjamin M. Neale
- Aiden Corvin
- James T.R. Walters
- Kai-How Farh
- Peter A. Holmans
- Phil Lee
- Brendan Bulik-Sullivan
- David A. Collier
- Hailiang Huang
- Tune H. Pers
- Ingrid Agartz
- Esben Agerbo
- Margot Albus
- Madeline Alexander
- Farooq Amin
- Silviu A. Bacanu
- Martin Begemann
- Richard A. Belliveau, Jr.
- Judit Bene
- Sarah E. Bergen
- Elizabeth Bevilacqua
- Tim B. Bigdeli
- Donald W. Black
- Richard Bruggeman
- Nancy G. Buccola
- Randy L. Buckner
- William Byerley
- Wiepke Cahn
- Guiqing Cai
- Dominique Campion
- Rita M. Cantor
- Vaughan J. Carr
- Noa Carrera
- Stanley V. Catts
- Kimberley D. Chambert
- Raymond C.K. Chan
- Ronald Y.L. Chan
- Eric Y.H. Chen
- Wei Cheng
- Eric FC. Cheung
- Siow Ann Chong
- C. Robert Cloninger
- David Cohen
- Nadine Cohen
- Paul Cormican
- Nick Craddock
- James J. Crowley
- David Curtis
- Michael Davidson
- Kenneth L. Davis
- Franziska Degenhardt
- Jurgen Del Favero
- Ditte Demontis
- Dimitris Dikeos
- Timothy Dinan
- Srdjan Djurovic
- Gary Donohoe
- Elodie Drapeau
- Jubao Duan
- Frank Dudbridge
- Naser Durmishi
- Peter Eichhammer
- Johan Eriksson
- Valentina Escott-Price
- Laurent Essioux
- Ayman H. Fanous
- Martilias S. Farrell
- Josef Frank
- Lude Franke
- Robert Freedman
- Nelson B. Freimer
- Marion Friedl
- Joseph I. Friedman
- Menachem Fromer
- Giulio Genovese
- Lyudmila Georgieva
- Ina Giegling
- Paola Giusti-Rodríguez
- Stephanie Godard
- Jacqueline I. Goldstein
- Vera Golimbet
- Srihari Gopal
- Jacob Gratten
- Lieuwe de Haan
- Christian Hammer
- Marian L. Hamshere
- Mark Hansen
- Thomas Hansen
- Vahram Haroutunian
- Annette M. Hartmann
- Frans A. Henskens
- Stefan Herms
- Joel N. Hirschhorn
- Per Hoffmann
- Andrea Hofman
- Mads V. Hollegaard
- David M. Hougaard
- Masashi Ikeda
- Inge Joa
- Antonio Julià
- René S. Kahn
- Luba Kalaydjieva
- Sena Karachanak-Yankova
- Juha Karjalainen
- David Kavanagh
- Matthew C. Keller
- James L. Kennedy
- Andrey Khrunin
- Yunjung Kim
- Janis Klovins
- James A. Knowles
- Bettina Konte
- Vaidutis Kucinskas
- Zita Ausrele Kucinskiene
- Hana Kuzelova-Ptackova
- Anna K. Kähler
- Claudine Laurent
- Jimmy Lee
- S. Hong Lee
- Sophie E. Legge
- Bernard Lerer
- Miaoxin Li
- Tao Li
- Kung-Yee Liang
- Jeffrey Lieberman
- Svetlana Limborska
- Carmel M. Loughland
- Jan Lubinski
- Jouko Lönnqvist
- Milan Macek
- Patrik K.E. Magnusson
- Brion S. Maher
- Wolfgang Maier
- Jacques Mallet
- Sara Marsal
- Manuel Mattheisen
- Morten Mattingsdal
- Robert W. McCarley
- Colm McDonald
- Andrew M. McIntosh
- Sandra Meier
- Carin J. Meijer
- Bela Melegh
- Ingrid Melle
- Raquelle I. Mesholam-Gately
- Andres Metspalu
- Patricia T. Michie
- Lili Milani
- Vihra Milanova
- Younes Mokrab
- Derek W. Morris
- Ole Mors
- Kieran C. Murphy
- Robin M. Murray
- Inez Myin-Germeys
- Bertram Müller-Myhsok
- Mari Nelis
- Igor Nenadic
- Deborah A. Nertney
- Gerald Nestadt
- Kristin K. Nicodemus
- Liene Nikitina-Zake
- Laura Nisenbaum
- Annelie Nordin
- Eadbhard O'Callaghan
- Colm O'Dushlaine
- F. Anthony O'Neill
- Sang-Yun Oh
- Ann Olincy
- Line Olsen
- Jim Van Os
- Christos Pantelis
- George N. Papadimitriou
- Sergi Papiol
- Elena Parkhomenko
- Michele T. Pato
- Tiina Paunio
- Milica Pejovic-Milovancevic
- Diana O. Perkins
- Olli Pietiläinen
- Jonathan Pimm
- Andrew J. Pocklington
- John Powell
- Alkes Price
- Ann E. Pulver
- Shaun M. Purcell
- Digby Quested
- Henrik B. Rasmussen
- Abraham Reichenberg
- Mark A. Reimers
- Alexander L. Richards
- Joshua L. Roffman
- Panos Roussos
- Douglas M. Ruderfer
- Veikko Salomaa
- Alan R. Sanders
- Ulrich Schall
- Christian R. Schubert
- Thomas G. Schulze
- Sibylle G. Schwab
- Edward M. Scolnick
- Rodney J. Scott
- Larry J. Seidman
- Jianxin Shi
- Engilbert Sigurdsson
- Teimuraz Silagadze
- Jeremy M. Silverman
- Kang Sim
- Petr Slominsky
- Jordan W. Smoller
- Hon-Cheong So
- Chris C.A. Spencer
- Eli A. Stahl
- Hreinn Stefansson
- Stacy Steinberg
- Elisabeth Stogmann
- Richard E. Straub
- Eric Strengman
- Jana Strohmaier
- T Scott Stroup
- Mythily Subramaniam
- Jaana Suvisaari
- Dragan M. Svrakic
- Jin P. Szatkiewicz
- Erik Söderman
- Srinivas Thirumalai
- Draga Toncheva
- Sarah Tosato
- Juha Veijola
- John Waddington
- Dermot Walsh
- Dai Wang
- Qiang Wang
- Bradley T. Webb
- Mark Weiser
- Dieter B. Wildenauer
- Nigel M. Williams
- Stephanie Williams
- Stephanie H. Witt
- Aaron R. Wolen
- Emily H.M. Wong
- Brandon K. Wormley
- Hualin Simon Xi
- Clement C. Zai
- Xuebin Zheng
- Fritz Zimprich
- Naomi R. Wray
- Kari Stefansson
- Peter M. Visscher
- Rolf Adolfsson
- Ole A. Andreassen
- Douglas H.R. Blackwood
- Elvira Bramon
- Joseph D. Buxbaum
- Anders D. Børglum
- Sven Cichon
- Ariel Darvasi
- Enrico Domenici
- Hannelore Ehrenreich
- Tõnu Esko
- Pablo V. Gejman
- Michael Gill
- Hugh Gurling
- Christina M. Hultman
- Nakao Iwata
- Assen V. Jablensky
- Erik G. Jönsson
- Kenneth S. Kendler
- George Kirov
- Jo Knight
- Todd Lencz
- Douglas F. Levinson
- Qingqin S. Li
- Jianjun Liu
- Anil K. Malhotra
- Steven A. McCarroll
- Andrew McQuillin
- Jennifer L. Moran
- Preben B. Mortensen
- Bryan J. Mowry
- Markus M. Nöthen
- Roel A. Ophoff
- Michael J. Owen
- Aarno Palotie
- Carlos N. Pato
- Tracey L. Petryshen
- Danielle Posthuma
- Marcella Rietschel
- Brien P. Riley
- Dan Rujescu
- Pak C. Sham
- Pamela Sklar
- David St Clair
- Daniel R. Weinberger
- Jens R. Wendland
- Thomas Werge
- Mark J. Daly
- Patrick F. Sullivan
- Michael C. O'Donovan
- Hailiang Huang
- Shengying Qin
- Akira Sawa
- Sibylle G. Schwab
- Rene Kahn
- Kyung Sue Hong
- Wenzhao Shi
- Ming Tsuang
- Masanari Itokawa
- Gang Feng
- Jianjun Liu
- Stephen J. Glatt
- Nakao Iwata
- Masashi Ikeda
- Xiancang Ma
- Jimmy Lee
- Jinsong Tang
- Yunfeng Ruan
- Ruize Liu
- Feng Zhu
- Yasue Horiuchi
- Byung Dae Lee
- Eun-Jeong Joo
- Woojae Myung
- Kyooseob Ha
- Hong-Hee Won
- Ji Hyung Baek
- Young Chul Chung
- Sung-Wan Kim
- Dieter B. Wildenauer
- Agung Kusumawardhani
- Wei J. Chen
- Hai-Gwo Hwu
- Kang Sim
- Akitoyo Hishimoto
- Ikuo Otsuka
- Ichiro Sora
- Tomoko Toyota
- Takeo Yoshikawa
- Hiroshi Kunugi
- Kotaro Hattori
- Sayuri Ishiwata
- Shusuke Numata
- Tetsuro Ohmori
- Makoto Arai
- Yuji Ozeki
- Kumiko Fujii
- Se Joo Kim
- Heon-Jeong Lee
- Yong Min Ahn
- Se Hyun Kim
- Kazufumi Akiyama
- Kazutaka Shimoda
- Makoto Kinoshita
- Journal volume & issue
-
Vol. 26,
no. 5
p. 106701
Abstract
Summary: Genetics have nominated many schizophrenia risk genes and identified convergent signals between schizophrenia and neurodevelopmental disorders. However, functional interpretation of the nominated genes in the relevant brain cell types is often lacking. We executed interaction proteomics for six schizophrenia risk genes that have also been implicated in neurodevelopment in human induced cortical neurons. The resulting protein network is enriched for common variant risk of schizophrenia in Europeans and East Asians, is down-regulated in layer 5/6 cortical neurons of individuals affected by schizophrenia, and can complement fine-mapping and eQTL data to prioritize additional genes in GWAS loci. A sub-network centered on HCN1 is enriched for common variant risk and contains proteins (HCN4 and AKAP11) enriched for rare protein-truncating mutations in individuals with schizophrenia and bipolar disorder. Our findings showcase brain cell-type-specific interactomes as an organizing framework to facilitate interpretation of genetic and transcriptomic data in schizophrenia and its related disorders.
