Детские инфекции (Москва) (Aug 2015)

THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C

  • A. Leybman,
  • L. I. Nikolaeva,
  • G. V. Sapronov,
  • E. I. Shestakova,
  • E. I. Samokhvalov,
  • O. B. Kovalev,
  • A. G. Pisarev,
  • L. I. Konovalova,
  • A. E. Grishechkin,
  • V. F. Uchaikin

DOI
https://doi.org/10.22627/2072-8107-2014-13-2-8-12
Journal volume & issue
Vol. 13, no. 2
pp. 8 – 12

Abstract

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The clinical and pathogenetic significance of determining HCV core-antigen (HCV core-Ag) in serum of children with hepatitis C was investigated firstly. A direct correlation between the concentration of HCV core-Ag and viral load (VL) was revealed (r = 0,91). Children with high core-Ag (above 2500 fmol/L) showed indirect evidence for the immunosuppressive action of HCV core-Ag and occurrence of liver fibrosis more frequent (p < 0,05). In this grouP of children the prevalence of HCV subtype 3a was revealed (p < 0,05).

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